Novadiscovery announces Nature Communication article on modeling the disruption of respiratory clinical trials due to attenuationson measures against COVID-19[feminine]
The model uses virtual populations and in silico trials to show impact on clinical trials and suggest adaptations to trial design
Lyon, France- 13 April 2022: Novadiscovery (NOVA), a leading health technology company using silicone clinical trials to predict drug efficacy and optimize clinical trial development, today announces the publication of a novel model of respiratory tract infections (RTIs) in Nature Communication to address uncertainties arising from non-pharmaceutical interventions (NPIs) against COVID-19 on clinical trials. The article was published in collaboration with NOVA’s partner, OM Pharma.
François-Henri Boissel, CEO, NOVA said“The pandemic and all related measures such as lockdowns have severely affected clinical trials across all indications, but the impact of reduced viral transmission and the resulting seasonal disruption of disease patterns on respiratory trials was particularly marked.Our model provides vital information on whether trials will still meet their endpoints, how to interpret clinical relevance, and potential adaptations to statistical analyzes and trial design – such as the number of recruitments – to maximize success and avoid delays in obtaining new treatments for patients.
NOVA’s modeling approach is rooted in systems biology and quantitative systems pharmacology. The document describes how the model was used to run silicone simulations of clinical trials with OM-85 from OM Pharma as prophylaxis of respiratory tract infections (RTIs) in virtual populations and in various scenarios for reducing viral transmissions due to NPIs.
The results led the authors of the article to argue for reporting variable measures of benefit, using an adaptive trial design, and tailored statistical analyses. The authors also cautioned that criteria for patient eligibility for trials will need to be reassessed as disease burden has been impacted by pandemic measures.
The complete paper “Modeling the disruption of respiratory disease clinical trials by non-pharmaceutical COVID-19 interventions”, can be found here.
For more information please contact:
François-Henri Boissel, Managing Director
Consilium Strategic Communications
Sukaina Virji, Kris Lam, Isabelle Abdou
Novadiscovery is a leading health technology company that uses silicone clinical trials to predict drug efficacy and optimize clinical trial development. The Company aims to improve R&D productivity and maximize patient outcomes by predicting the clinical benefit of a potential new drug candidate through computer simulation, prior to human trials.
Novadiscovery’s innovative approach builds on expertise in disease modeling and simulation accumulated over the past decade and combines mathematical models of diseases and potential new treatments with virtual patients in its integrated disease simulation platform. clinical trials, JINKO®.
Novadiscovery is headquartered in Lyon, France and has a team of around 30 scientists, engineers and clinicians who work at the interface of biology, pharmacology, mathematics and computer science.
For more information, please visit https://www.novadiscovery.com and follow us on Twitter @novadiscovery and linkedin.com/company/novadiscovery